| Team: | Fresno State Bulldogs |
| Year: | 2021 |
| Sport: | football |
| Conference: | Mountain West Conference |
| Division: | West Division |
| Short Conf: | MW |
| Record: | 10–3 |
| Conf Record: | 6–2 |
| Head Coach: | Kalen DeBoer |
| Hc Year: | 2nd |
| Hc Games: | regular season |
| Head Coach2: | Lee Marks |
| Hc Games2: | interim; bowl game |
| Off Coach: | Ryan Grubb |
| Oc Year: | 3rd |
| Off Scheme: | Air raid |
| Def Coach: | William Inge |
| Dc Year: | 2nd |
| Def Scheme: | Multiple 4–2–5 |
| Stadium: | Bulldog Stadium |
| Champion: | New Mexico Bowl champion |
| Bowl: | New Mexico Bowl |
| Bowl Result: | W 31–24 vs. UTEP |
The 2021 Fresno State Bulldogs football team represented California State University, Fresno as a member of the West Division of the Mountain West Conference (MW) during the 2021 NCAA Division I FBS football season. The Bulldogs were led by second-year head coach Kalen DeBoer during the regular season and Lee Marks as interim head coach for their bowl game. They compiled an overall record of 10–3 with a mark of 6–2 in conference play, plaching second in the MW's West Division. Fresno State was invited to the New Mexico Bowl, where they beat UTEP. The team played home games at Bulldog Stadium in Fresno, California.
See also: 2021 UConn Huskies football team.
See also: 2021 Oregon Ducks football team.
See also: 2021 Cal Poly Mustangs football team.
See also: 2021 UCLA Bruins football team.
See also: 2021 UNLV Rebels football team.
See also: 2021 Hawaii Rainbow Warriors football team.
See also: 2021 Wyoming Cowboys football team.
See also: 2021 Nevada Wolf Pack football team.
See also: 2021 San Diego State Aztecs football team.
See also: 2021 Boise State Broncos football team.
See also: 2021 New Mexico Lobos football team.
See also: 2021 San Jose State Spartans football team.
See also: 2021 UTEP Miners football team and 2021 New Mexico Bowl.