| Champ: |  Sebastian Korda |
| Runner: |  Marco Cecchinato |
| Score: | 6–2, 6–4 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| After Name: | Emilia-Romagna Open – Singles |
| Before Name: | Internazionali di Tennis Emilia Romagna |
See main article: article and 2021 Emilia-Romagna Open.
This was the third edition of the tournament, primarily created due to the one-week delay of the 2021 French Open.[1]
Sebastian Korda won his first ATP Tour singles title, defeating Marco Cecchinato in the final, 6–2, 6–4 without dropping a set. By winning the tournament, Korda became the first American male tennis player to win on European clay since Sam Querrey in 2010.[2]
The top four seeds receive a bye into the second round.