| Year: | 2021 |
| Team: | Delaware State Hornets |
| Sport: | football |
| Conference: | Mid-Eastern Athletic Conference |
| Short Conf: | MEAC |
| Record: | 5–6 |
| Conf Record: | 2–3 |
| Head Coach: | Rod Milstead |
| Hc Year: | 4th |
| Off Coach: | Steve Azzanesi |
| Oc Year: | 2nd season |
| Def Coach: | Leandre Creamer |
| Dc Year: | 1st |
| Stadium: | Alumni Stadium |
The 2021 Delaware State Hornets football team represented Delaware State University as a member of the Mid-Eastern Athletic Conference (MEAC) in the 2021 NCAA Division I FCS football season. The Hornets, led by fourth-year head coach Rod Milstead, played their home games at Alumni Stadium.