| Date: | 6–12 September |
| Edition: | 23rd |
| Surface: | Clay |
| Location: | Seville, Spain |
| Champs: |  Pedro Martínez |
| Champd: | David Vega Hernández / Mark Vervoort |
| Before Year: | 2019 |
The 2021 Copa Sevilla was a professional tennis tournament played on clay courts. It was the 23rd edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Seville, Spain between 6 and 12 September 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Spain | Pablo Andújar | 74 | 1 | |
| Spain | Pedro Martínez | 75 | 2 | |
| Spain | Roberto Carballés Baena | 95 | 3 | |
| Spain | Carlos Taberner | 105 | 4 | |
| Spain | Bernabé Zapata Miralles | 116 | 5 | |
 Italy | Federico Gaio | 159 | 6 | |
| Marcelo Tomás Barrios Vera | 172 | 7 | ||
| Italy | Lorenzo Giustino | 238 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using protected rankings:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Luciano Darderi
Emilio Nava Benjamín Winter LópezSee main article: 2021 Copa Sevilla – Singles.
Pedro Martínez def. Roberto Carballés Baena 6–4, 6–1.See main article: 2021 Copa Sevilla – Doubles.
David Vega Hernández / Mark Vervoort def. Javier Barranco Cosano / Sergio Martos Gornés 6–3, 6–7(7–9), [10–7].