See main article: article and 2021 Christus Health Pro Challenge.
Allura Zamarripa and Maribella Zamarripa were the defending champions[1] but chose not to participate.
Giuliana Olmos and Marcela Zacarías won the title, defeating Misaki Doi and Katarzyna Kawa in the final, 7–5, 1–6, [10–5].