| Club: | Botafogo |
| Season: | 2021 |
| Manager: | Marcelo Chamusca (until 13 July) Ricardo Resende (caretaker, from 16 July) |
| Stadium: | Estádio Nilton Santos |
| League: | Campeonato Brasileiro Série B |
| League Result: | 1st (promoted) |
| League2: | Campeonato Carioca |
| League2 Result: | Campeonato Carioca |
| Cup1: | Copa do Brasil |
| Cup1 Result: | Copa do Brasil |
| League Topscorer: | Rafael Navarro (15) |
| Season Topscorer: | Rafael Navarro (16) |
| Prevseason: | 2020 |
| Nextseason: | 2022 |
The 2021 season was the 117th in the history of Botafogo Football and Rowing Club and the second in a row in the second division of Brazilian football. It participated in the Série B, the Campeonato Carioca and the Copa do Brasil.
See main article: 2021 Campeonato Brasileiro Série B.