| Champ: |  Alfie Hewett Gordon Reid |
| Runner: |  Stéphane Houdet Nicolas Peifer |
| Score: | 7–5, 7–6(7–3) |
| Before Name: | Australian Open – Wheelchair men's doubles |
| After Name: | Australian Open – Wheelchair men's doubles |
See main article: 2021 Australian Open.
Defending champions Alfie Hewett and Gordon Reid defeated Stéphane Houdet and Nicolas Peifer in the final, 7–5, 7–6(7–3) to win the men's doubles wheelchair tennis title at the 2021 Australian Open. It was their first step towards a Grand Slam.