| Competition: | Macedonian First League |
| Season: | 2021–22 |
| Winners: | Shkupi 1st domestic title |
| Relegated: | Borec Pelister |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Shkupi |
| Continentalcup2: | Europa Conference League |
| Continentalcup2 Qualifiers: | Akademija Pandev Shkëndija Makedonija G.P. |
| League Topscorer: | Sunday Adetunji (20 goals) |
| Dates: | 10 August 2021 – 15 May 2022 |
| Biggest Home Win: | Shkupi 5–0 Pelister (21 November 2021) Akademija Pandev 5–0 Skopje (20 February 2022) Akademija Pandev 5–0 Borec (9 March 2022) Tikvesh 5–0 Borec (23 April 2022) |
| Biggest Away Win: | Pelister 0–3 Bregalnica (24 October 2021) Borec 1–4 Renova (21 November 2021) |
| Highest Scoring: | Renova 5–2 Bregalnica (26 September 2021) |
| Matches: | 198 |
| Total Goals: | 469 |
| Longest Wins: | 6 games Makedonija G.P. Shkupi |
| Longest Unbeaten: | 16 games Shkupi |
| Longest Winless: | 23 games Pelister |
| Longest Losses: | 5 games Borec Pelister |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Updated: | 21 May 2022 |
The 2021–22 Macedonian First League was the 30th season of the Macedonian First Football League, the highest football league of North Macedonia. It began on 8 August 2021 and ended on 15 May 2022. Shkëndija are the defending champions, having won their fourth title in 2020–21.
Relegated to 2021–22 Second League |
Relegated to 2022–23 Second League |
| Akademija Pandev | Borec | Bregalnica | Makedonija G.P. | Pelister | Rabotnički |
|---|---|---|---|---|---|
| Blagoj Istatov Stadium UEFA | Zoran Paunov Stadium | City Stadium Štip | Gjorče Petrov Stadium | Petar Miloševski Stadium | Toše Proeski Arena UEFA |
| Capacity: 9,200 | Capacity: 2,000 | Capacity: 4,000 | Capacity: 3,000 | Capacity: 9,100 | Capacity: 36,460 |
| Renova Shkëndija | Shkupi | Skopje | Struga | Tikvesh | |
| Tetovo Stadium | Čair Stadium Skopje | Železarnica Stadium | Gradska Plaža Stadium | City Stadium Kavadarci | |
| Capacity: 15,000 | Capacity: 6,000 | Capacity: 3,000 | Capacity: 2,500 | Capacity: 7,500 | |
Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.
| Team | Manager | Captain | Kit manufacturer | Shirt sponsor |
|---|---|---|---|---|
| Akademija Pandev | Vacant |  | Sportika SA | Strumka, JOXX, Elenica |
| Borec | | | Legea | Brako |
| Bregalnica | | | Puma | Gogov Hotel |
| Makedonija G.P. | | | Givova | betinasia, Tesla |
| Pelister | | | Legea | SN Broker |
| Rabotnički | | | Joma | Seavus |
| Renova | | | Jako | Renova |
| Shkëndija |  | | Macron | Ecolog |
| Shkupi | | | Sunrise | – |
| Skopje | | | Givova | bet2day |
| Struga | | | Macron | Trim & Lum |
| Tikvesh | | | Joma | Klimi.mk, Sinalco |
Every team will play three times against each other team for a total of 33 matches. The first 22 matchdays will consist of a regular double round-robin schedule. The league standings at this point will then be used to determine the games for the last 11 matchdays.
The table lists the positions of teams after each week of matches. In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.
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| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Sunday Adetunji | Shkupi | 20 |
| 2 | Martin Mirčevski | Akademija Pandev | 16 |
| 3 | Remzifaik Selmani | Renova | 15 |
| 4 | Ermedin Adem | Makedonija G.P. | 11 |
| 5 | Marjan Altiparmakovski | Bregalnica | 10 |
 Sindrit Guri | Shkëndija | ||
| Ljupcho Doriev | Shkëndija | ||
| 8 |  Milan Đokić | Bregalnica | 9 |
| Martin Stojanov | Bregalnica | ||
| 10 | Freddy Álvarez | Shkupi | 8 |
 Anael Barga | Tikvesh | ||
| Nemanja Bosančić | Struga | ||
| Sefer Emini | Makedonija G.P. | ||
| Arbi Vosha | Makedonija G.P. | ||