| Club: | Willem II |
| Season: | 2021–22 |
| Chrtitle: | Chairman |
| Chairman: | Jack Buckens |
| Mgrtitle: | Head coach |
| Manager: | Fred Grim |
| Stadium: | Koning Willem II Stadion |
| League: | Eredivisie |
| League Result: | 17th (relegated) |
| Cup1: | KNVB Cup |
| Cup1 Result: | First round |
| League Topscorer: | Ché Nunnely (6) |
| Season Topscorer: | Ché Nunnely (6) |
| Highest Attendance: | 9,700 (vs. Feyenoord, 15 August 2021) |
| Lowest Attendance: | 9,700 (vs. Feyenoord, 15 August 2021) |
| Average Attendance: | 9,700 |
| Largest Win: | 3-0 (vs. Vitesse, 22 August 2021) |
| Largest Loss: | 0–4 (vs. Feyenoord, 15 August 2021) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 125th season in the existence of Willem II and the club's eighth consecutive season in the top flight of Dutch football. In addition to the domestic league, Willem II participated in this season's editions of the KNVB Cup.
See main article: 2021–22 Eredivisie.
The league fixtures were announced on 11 June 2021.[1]
See main article: 2021–22 KNVB Cup.