| Club: | Vitória S.C. |
| Season: | 2021–22 |
| Chrtitle: | Chairman |
| Chairman: | Miguel Pinto Lisboa |
| Mgrtitle: | Manager |
| Manager: | Pepa |
| Stadium: | Estádio D. Afonso Henriques |
| League: | Primeira Liga |
| League Result: | 6th |
| Cup1: | Taça de Portugal |
| Cup1 Result: | Fourth round |
| Cup2: | Taça da Liga |
| Cup2 Result: | Third round |
| League Topscorer: | Óscar Estupiñán (15) |
| Season Topscorer: | Óscar Estupiñán (16) |
| Pattern La1: | _guimaraes2021h |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season is the 72nd season in the existence of Vitória S.C. and the club's 15th consecutive season in the top flight of Portuguese football. In addition to the domestic league, Vitória S.C. are participating in this season's edition of the Taça de Portugal and the Taça da Liga.
See main article: 2021–22 Primeira Liga.
See main article: 2021–22 Taça de Portugal.
See main article: 2021–22 Taça da Liga.
|-! colspan=18 style=background:#dcdcdc; text-align:center|Goalkeepers|-! colspan=18 style=background:#dcdcdc; text-align:center|Defenders|-! colspan=18 style=background:#dcdcdc; text-align:center|Midfielders|-! colspan=18 style=background:#dcdcdc; text-align:center|Forwards|-|}