| Sport: | basketball |
| Year: | 2021-22 |
| Prev Year: | 2020-21 |
| Next Year: | 2022-23 |
| Team: | USC Trojans |
| Conference: | Pac-12 Conference |
| Short Conf: | Pac-12 |
| Record: | 26–8 |
| Conf Record: | 14–6 |
| Aprank: | 22 |
| Head Coach: | Andy Enfield |
| Hc Year: | 9th |
| Asst Coach1: | Chris Capko |
| Ac1 Year: | 6th |
| Asst Coach2: | Eric Mobley |
| Ac2 Year: | 4th |
| Asst Coach3: | Jay Morris |
| Ac3 Year: | 1st |
| Arena: | Galen Center (Capacity: 10,258) |
| Champion: | Wooden Legacy champions |
| Tourney: | NCAA tournament |
| Tourney Result: | First Round |
The 2021–22 USC Trojans men's basketball team represented the University of Southern California during the 2021–22 NCAA Division I men's basketball season. The Trojans are led by 9th-year head coach Andy Enfield and played their home games at the Galen Center for the 16th season in Los Angeles as members of the Pac-12 Conference. They finished the season 26–8, 14–6 in Pac-12 Play to finish in third place. As the No. 3 seed in the Pac-12 tournament, they defeated Washington in the quarterfinals before losing in the semifinals to UCLA. They received an at-large bid to the NCAA tournament as the No. 7 seed in the Midwest Region, where they lost in the First Round to Miami (FL).
See also: 2020-21 USC Trojans men's basketball team.
The USC Trojans finished the 2020–21 season with a 25–8 overall record, and a 15–5 conference record. They finished in second place in the Pac-12 Conference. They were a part of the Pac-12 tournament they played against the Utah in the Quarterfinals and won in 2OT by the score of 91–85, they would move on to the semifinals but would lose to Colorado and would be eliminated from the tournament. They would then be invited to compete in the 2021 NCAA tournament and would get wins against Drake, Kansas, Oregon, but would then be eliminated by the Gonzaga Bulldogs in the Elite Eight.
| Name | Number | Pos. | Height | Weight | Year | Hometown | Reason for Departure | |
|---|---|---|---|---|---|---|---|---|
| Talin Lewis | 0 | G | 6'4" | 180 | Junior | Walk-on; left the team | ||
| 2 | G | 6'2" | 165 | Redshirt Senior | Declared for the 2021 NBA draft; went Undrafted | |||
| 4 | F | 7'0" | 215 | Freshman | Declared for the 2021 NBA draft; selected 3rd overall pick by the Cleveland Cavaliers | |||
| McKay Anderson | 14 | G | 6'5" | 190 | Redshirt Senior | Walk-on; graduated | ||
| Noah Baumann | 30 | G | 6'6" | 215 | Redshirt Junior | Transferred to Georgia |
|-!colspan=9 style=| Regular season|-!colspan=9 style=| Pac-12 Tournament|-!colspan=9 style=| NCAA tournament Source:[1]
Wooden Legacy semifinals
Wooden Legacy Championship Game
See also: 2021–22 NCAA Division I men's basketball rankings. *AP does not release post-NCAA Tournament rankings.
^Coaches did not release a Week 1 poll.