| Year: | 2021–22 |
| Team: | Samford Bulldogs |
| Sport: | basketball |
| Conference: | Southern Conference |
| Short Conf: | SoCon |
| Record: | 21–11 |
| Conf Record: | 10–8 |
| Head Coach: | Bucky McMillan |
| Hc Year: | 2nd |
| Assoc Coach: | Mitch Cole |
| Asst Coach2: | Zach Gillion |
| Asst Coach3: | Neb Exantus |
| Stadium: | Pete Hanna Center |
The 2021–22 Samford Bulldogs men's basketball team represented Samford University in the 2021–22 NCAA Division I men's basketball season. The Bulldogs, led by second-year head coach Bucky McMillan, played their home games at the Pete Hanna Center in Homewood, Alabama as a member of the Southern Conference. They finished the season 21–11, 10–8 in SoCon play to finish in a tie for third place. As the No. 3 seed in the SoCon tournament, they defeated UNC Greensboro before losing to Furman in the semifinals.
In a season limited due to the ongoing COVID-19 pandemic, the Bulldogs finished the 2020–21 season 6–13, 2–9 in SoCon play to finish in last place. They lost to Mercer in the first round of the SoCon tournament.[1]
|-!colspan=12 style=| Non-conference regular season|-!colspan=12 style=| SoCon regular season|-!colspan=9 style=| SoCon tournamentSources[2] [3]