| Greek Cup | |
| Year: | 2021–22 |
| Country: | Greece |
| Num Teams: | 119 |
| Defending Champions: | PAOK |
| Champions: | Panathinaikos (19th title) |
| Runner-Up: | PAOK |
| Continentalcup1: | Europa Conference League |
| Matches: | 128 |
| Goals: | 325 |
| Top Goal Scorer: | Vangelis Tsevanedis (6 goals) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Greek Football Cup was the 80th edition of the Greek Football Cup. The winner of the Cup qualified for the next season's Europa Conference League third qualifying round.
| Round | Date(s) | Fixtures | Clubs | New entries | Leagues entering |
|---|---|---|---|---|---|
| First Round | 28, 29 August & 5 September 2021 | 36 | 128 → 89 | 79 | Gamma Ethniki |
| Second Round | 11, 12 September 2021 | 20 | 89 → 69 | none | none |
| Third Round | 25, 26, 29 September 2021 | 23 | 69 → 46 | 26 | Super League 2 |
| Fourth Round | 6 October 2021 | 9 | 46 → 34 | none | none |
| Fifth Round | 26, 27 October & 3 November 2021 | 12 | 28 → 16 | 10 | Super League 1, places 5–14 |
| Round of 16 | 1, 2, 22, 23 December 2021 | 16 | 16 → 8 | 4 | Super League 1, places 1–4 |
| Quarter-finals | 19, 20, 26 January & 9 February 2022 | 8 | 8 → 4 | none | none |
| Semi-finals | 20, 21 & 27 April 2022 | 4 | 4 → 2 | ||
| Final | 21 May 2022 | 1 | 2 → 1 |
The draw took place on 12 August 2021.[2]
|colspan="3" style="background-color:#D0D0D0" align=center|28 August 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|29 August 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|5 September 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|N/A|}
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The draw took place on 6 September 2021.[3]
|colspan="3" style="background-color:#D0D0D0" align=center|11 September 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|12 September 2021|}
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The draw took place on 21 September 2021.[4]
|colspan="3" style="background-color:#D0D0D0" align=center|25 September 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|26 September 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|29 September 2021|}
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The draw took place on 30 September 2021.[5]
|colspan="3" style="background-color:#D0D0D0" align=center|6 October 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|N/A|}
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The draw took place on 14 October 2021.[6]
|colspan="3" style="background-color:#D0D0D0" align=center|26 October 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|27 October 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|28 October 2021|-|colspan="3" style="background-color:#D0D0D0" align=center|3 November 2021|}
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Each tie in the knockout phase, apart from the quarter-finals and the semi-finals, was played by a single match. If the score was level at the end of normal time, extra time was played, followed by a penalty shoot-out if the score was still level. In the quarter-finals and the semi-finals were played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, the away goals rule was applied, i.e. the team that scored more goals away from home over the two legs advanced. If away goals were also equal, then extra time was played. The away goals rule was again applied after extra time, i.e. if there were goals scored during extra time and the aggregate score was still level, the visiting team advanced by virtue of more away goals scored. If no goals were scored during extra time, the winners were decided by a penalty shoot-out. In the round of 16, if the score was level at the end of normal time the two-legged rule was applied.
The mechanism of the draws for each round is as follows:
The draw took place on 18 November 2021.[7] The first legs were played on 1 December 2021 and the second legs were played on 22 and 23 December 2021.
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PAOK won 4–2 on aggregate.----Aris won 5–1 on aggregate.----AEK Athens won 5–1 on aggregate.----Olympiacos won 4–3 on aggregate.----Panathinaikos won 2–1 on aggregate.----Anagennisi Karditsa won 6–0 on aggregate.----Lamia won 3–0 on aggregate.----Panetolikos won 3–0 on aggregate.
The draw took place on 29 December 2021.[8] Former Greek international and member of the UEFA Euro 2004 squad, Kostas Katsouranis, made the draw using a manually operated lottery ball cage.
|}
Lamia won 1–0 on aggregate.----Olympiacos won 4–3 on aggregate.----Panathinaikos won 5–0 on aggregate.----PAOK won 2–1 on aggregate.
The draw took place on 29 December 2021, after the quarter-final draw.[8]
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Panathinaikos won 3–0 on aggregate----1–1 on aggregate; PAOK won on away goals
See main article: 2022 Greek Football Cup final.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Vangelis Tsevanedis | AE Lefkimmi | 6 |
| 2 | Charalampos Samios | Ethnikos Piraeus | 4 |
| Ilias Ignatidis | Poseidon Nea Michaniona | ||
| 4 |  Alberto Simoni | Tilikratis | 3 |
| Georgios Mouliatos | Diavolitsi | ||
 Besart Ibraimi | Xanthi | ||
| Nikolaos Spiliotis | AO Ypato | ||
| Marios Ogkmpoe | AEL | ||
| Nikos Karelis | Panetolikos | ||
| Fábio Tavares | Ilioupoli | ||
| Georgios Mavris | A.O. Agios Nikolaos |