| Club: | Twente |
| Season: | 2021–22 |
| Chrtitle: | Chairman |
| Chairman: | Paul van der Kraan |
| Mgrtitle: | Head coach |
| Manager: | Ron Jans |
| Stadium: | De Grolsch Veste |
| League: | Eredivisie |
| League Result: | 4th |
| Cup1: | KNVB Cup |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Ricky van Wolfswinkel (16) |
| Season Topscorer: | Ricky van Wolfswinkel (17) |
| Highest Attendance: | 30,000 (vs. Heracles Almelo, 5 November 2021) |
| Lowest Attendance: | 0 (all games from mid-November onwards) |
| Average Attendance: | 14,300 |
| Largest Win: | 4–1 (vs. Vitesse (a), 19 September 2021) |
| Largest Loss: | 2–5 (vs. PSV (a), 30 October 2021) |
| Pattern La1: | _twente2021h |
| Pattern B1: | _twente2021h |
| Pattern Ra1: | _twente2021h |
| Pattern Sh1: | _twente2021h |
| Pattern So1: | _twente2021h |
| Leftarm1: | DD0000 |
| Body1: | DD0000 |
| Rightarm1: | DD0000 |
| Shorts1: | DD0000 |
| Socks1: | DD0000 |
| Pattern La2: | _twente2021a |
| Pattern B2: | _twente2021a |
| Pattern Ra2: | _twente2021a |
| Pattern Sh2: | _twente2021a |
| Pattern So2: | _twente2021a |
| Leftarm2: | 000044 |
| Body2: | 000044 |
| Rightarm2: | 000044 |
| Shorts2: | 000044 |
| Socks2: | 000044 |
| Pattern La3: | _twente2021t |
| Pattern B3: | _twente2021t |
| Pattern Ra3: | _twente2021t |
| Pattern Sh3: | _twente2021t |
| Pattern So3: | _twente2021t |
| Leftarm3: | FFFFFF |
| Body3: | FFFFFF |
| Rightarm3: | FFFFFF |
| Shorts3: | FFFFFF |
| Socks3: | FFFFFF |
| Updated: | 15 May 2022 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 57th season in the existence of FC Twente and the club's third consecutive season in the top flight of Dutch football. In addition to the domestic league, FC Twente participated in this season's edition of the KNVB Cup.
See main article: 2021–22 Eredivisie.
The league fixtures were announced on 11 June 2021.[2]
See main article: 2021–22 KNVB Cup.