| Pixels: | 200px |
| Competition: | Betking Ethiopian Premier League |
| Season: | 2021–22 |
| Dates: | 17 October 2021 – 2 July 2022 |
| Winners: | Saint George 15th title |
| Relegated: | Sebeta City F.C., Jimma Aba Jifar F.C., Addis Ababa City F.C. |
| Continentalcup1: | Champions League |
| Continentalcup2: | Confederation Cup |
| Continentalcup2 Qualifiers: | Fasil Kenema S.C. |
| Matches: | 240 |
| League Topscorer: |  Yigezu Bogale (16) |
| Longest Unbeaten: | (26 games) Saint George S.C. |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021-22 Ethiopian Premier League is the 75th season of top-tier football in Ethiopia (23rd season as the Premier League). The season started on October 17, 2021.[1] The first round of matches were held at Hawassa stadium and Dire Dawa Stadium, while the second round of matches were held at Adama and Bahir dar Stadium.
The following 16 clubs competing in the Ethiopian Premier League during the 2021–22 season.
| Club | Position2019-20 | Top Division | Location | Stadium | Capacity | ||
|---|---|---|---|---|---|---|---|
| Titles | Last title | ||||||
| Adama City | N/A | 0 | Never | Adama | Abebe Bikila Stadium | 4,000 | |
| Addis Ababa City | N/A | 0 | Never | Addis Abeba | Addis Abeba | 35,000 | |
| Arba Minch | N/A | 0 | Never | Arba Minch | Arba Minch Stadium | 5,000 | |
| Bahir Dar Kenema | N/A | 0 | Never | Bahir Dar | Bahir Dar Stadium | 60,000 | |
| Dire Dawa City | N/A | 0 | Never | Dire Dawa | Dire Dawa | 18,000 | |
| Ethiopian Coffee | 2 | 2 | 2010-11 | Addis Abeba | Addis Abeba | 35,000 | |
| Fasil Kenema | 1 | 1 | 2020-21 | Gondar | Fasiledes | 20,000 | |
| Hadiya Hossana | N/A | 0 | Never | Hossana | Abiy Hersamo Stadium | 5,000 | |
| Hawassa City | N/A | 2 | 2006-07 | Hawassa | Hawassa Stadium | 15,000 | |
| Jimma Aba Jifar | N/A | 1 | 2017-18 | Jimma | Jimma Stadium | 15,000 | |
| Mekelakeya | N/A | 11 | 1988-89 | Addis Abeba | Addis Abeba | 35,000 | |
| Saint George | N/A | 29 | 2016-17 | Addis Abeba | Addis Abeba | 35,000 | |
| Sebeta City | N/A | 0 | Never | Sebeta | Sebeta Stadium | 5,000 | |
| Sidama Coffee | N/A | 0 | Never | Hawassa | Hawassa Stadium | 25,000 | |
| Wolaitta Dicha | N/A | 0 | Never | Wolaita Sodo | Sodo Stadium | 30,000 | |
| Wolkite City | N/A | 0 | Never | Wolkite | Wolkite Stadium | 1,500 | |
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Yigezu Bogale | Sidama Coffee | 16 |
| 2 |  Richmond | Addis Ababa | 14 |
| Biruk Beyene | Hawassa | ||
| Getaneh Kebede | Wolkite | ||
| Abubeker Nassir | Ethiopian Coffee | ||
| 6 | Ismaïl Ouro-Agoro | Saint George | 12 |
| 7 | Henok Ayele | Dire Dawa | 10 |
| 8 | Fitsum Tilahun | Addis Ababa | 9 |
| 9 | Okiki Afolabi | Fasil Kenema | 8 |
| Osei Mawuli | Wolaitta Dicha |