| Mode: | Women's Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | DePaul Blue Demons |
| Conference: | Big East Conference |
| Short Conf: | Big East |
| Record: | 22–11 |
| Conf Record: | 14–6 |
| Head Coach: | Doug Bruno |
| Hc Year: | 36th |
| Asst Coach1: | Jill M. Pizzotti |
| Asst Coach2: | Candis Blankson |
| Asst Coach3: | Lisa Ryckbosch |
| Stadium: | Wintrust Arena |
| Bowl: | NCAA tournament |
| Bowl Result: | First Four |
The 2021–22 DePaul Blue Demons women's basketball team represented DePaul University during the 2021–22 NCAA Division I women's basketball season. The Blue Demons were led by thirty-sixth year head coach Doug Bruno and played their home games at the Wintrust Arena as members of the Big East Conference.
DePaul finished the 2020–21 season 14–10, 11–5 in Big East play to finish in fourth place.[1] [2] As the fourth seed in the Big East tournament they lost in the Quarterfinals to Villanova. They received an at-large invitation to the WNIT, where they played in the Rockford Regional. They lost in the First Round to Saint Louis and lost their consolation game to Drake.
Source:[3]
|-!colspan=9 style=| Exhibition|-!colspan=9 style=| Regular season|-!colspan=12 style=|Big East Women's Tournament|-!colspan=9 style="|NCAA tournament
See main article: 2021–22 NCAA Division I women's basketball rankings.