The 2021–22 Danish 2nd Division started with a group of twelve teams. After 22 rounds the group was split in a promotion group and a relegation group. The top two teams of the promotion group was promoted to the 2022–23 Danish 1st Division.
Kolding IF and Skive IK finished the 2020–21 season of the Danish 1st Division in 11th and 12th place, respectively, and were relegated to the 2nd Division. They replaced Nykøbing FC and Jammerbugt FC, who were promoted to the 2021–22 Danish 1st Division.
| Club | Location | Stadium | Turf | Capacity | 2020–21 position | |
|---|---|---|---|---|---|---|
| Aarhus | Riisvangen Stadium | Natural | 5,000 | |||
| Gladsaxe | Gladsaxe Stadium | Natural | 13,800 | |||
| Copenhagen | Østerbro Stadium | Natural | 7,000 | |||
| Brabrand | Brabrand Stadion | Natural | 1,000 | |||
| Frederiksberg | Frederiksberg Idrætspark | Artificial | 5,000 | |||
| Hellerup | Gentofte Sportspark | Natural | 15,000 | |||
| Hillerød | Artificial | 5,000 | ||||
| Kolding | Autocentralen Park | Natural | 10,000 | |||
| Middelfart | Middelfart Stadion | Natural | 4,100 | |||
| Næstved | Tintshop Park | Natural | 7,500 | |||
| Skive | SPAR Nord Arena | Natural | 10,000 | |||
| Thisted | Sparekassen Thy Arena | Natural | 3,000 |
The top 6 teams will compete for 2 spots in the 2022–23 Danish 1st Division.Points and goals carried over in full from the regular season.
The bottom 6 teams will compete to avoid the 2 relegations spots to the 2022–23 Danish 3rd Division.Points and goals carried over in full from the regular season.