| Cupa României | |
| Year: | 2021–22 |
| Other Title: | Cupa României 2021–22 |
| Country: | Romania |
| Defending Champions: | Universitatea Craiova |
| Champions: | Sepsi OSK |
| Runner-Up: | Voluntari |
| Continentalcup1: | Conference League |
| Continentalcup1 Qualifiers: | Sepsi OSK |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Cupa României was the 84th season of the annual Romanian primary football knockout tournament. The winner qualified for the second qualifying round of the 2022–23 UEFA Europa Conference League. Times up to 30 October 2021 and from 26 March 2022 are EEST (UTC+3). Times between 31 October 2021 and 27 March 2022 are EET (UTC+2).
Source:[1]
| Round | Draw date | First match date | |
|---|---|---|---|
| First Round | 21 July 2021 | 28 July 2021 | |
| Second Round | 2 August 2021 | 11 August 2021 | |
| Third Round | 18 August 2021 | 24 August 2021 | |
| Fourth Round | 30 August 2021 | 7 September 2021 | |
| Round of 32 | 9 September 2021 | 21 September 2021 | |
| Round of 16 | 5 October 2021 | 26 October 2021 | |
| Quarter-finals | 8 November | 1 December 2021 | |
| Semi-finals | 24 February | 20 April 2022 / 11 May 2022 | |
| Final | – | 19 May 2022 |
The matches were played on 21, 22 and 23 September 2021.|colspan="3" style="background-color:#97DEFF"|21 September 2021|-|colspan="3" style="background-color:#97DEFF"|22 September 2021|-|colspan="3" style="background-color:#97DEFF"|23 September 2021|}
The matches were played on 26, 27 and 28 October 2021.|colspan="3" style="background-color:#97DEFF"|26 October 2021|-|colspan="3" style="background-color:#97DEFF"|27 October 2021|-|colspan="3" style="background-color:#97DEFF"|28 October 2021|}
The matches were played on 30 November, 1 and 2 December 2021.|colspan="3" style="background-color:#97DEFF"|30 November 2021|-|colspan="3" style="background-color:#97DEFF"|1 December 2021|-|colspan="3" style="background-color:#97DEFF"|2 December 2021|}
|}
See main article: 2022 Cupa României final.