See main article: 2020 São Paulo Challenger de Tênis.
This was the first edition of the tournament. It was originally scheduled to take place in Florianópolis (hard court) but was relocated to São Paulo (clay court) and took the São Paulo Challenger de Tênis namesake after restrictions in Santa Catarina state due to the COVID-19 pandemic.[1]
Felipe Meligeni Alves won the title after defeating Frederico Ferreira Silva 6–2, 7–6(7–1) in the final.