| Champ: |  Karolína Plíšková |
| Runner: |  Madison Keys |
| Score: | 6–4, 4–6, 7–5 |
| Draw: | 30 (4 / 4) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | Brisbane International – Women's singles |
| After Name: | Brisbane International – Women's singles |
| After Year: | 2024 |
See main article: 2020 Brisbane International.
Karolína Plíšková was the defending champion and successfully defended her title, defeating Madison Keys in the final, 6–4, 4–6, 7–5.[1] Plíšková won the title after saving a match point Naomi Osaka had against her in the semifinals.
The top two seeds received a bye into the second round.