| Competition: | Super League Greece 2 |
| Winners: | Ionikos |
| Promoted: | Ionikos |
| Relegated: | Panachaiki Doxa Drama |
| League Topscorer: | Matías Castro (15 goals) |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
| Season: | 2020–21 |
| Dates: | [1] [2] [3] |
The 2020–21 Super League 2 was the second season of the Super League 2, the second-tier Greek professional league for association football clubs, since restructuring of the Greek football league system.
Season's start has been delayed due to the COVID-19 second lockdown in Greece that began in November 2020 and started on 16 January 2021.
The following teams have changed division since the 2019–20 season.
Promoted from Gamma Ethniki
Relegated from Super League
Promoted to Super League
Relegated to Football League
Relegated to Gamma Ethniki
The following 12 clubs are competing in the Super League 2 during the 2020–21 season.
| Team | City | Stadium | Capacity |
|---|---|---|---|
| Apollon Larissa | 16,118 | ||
| Chania | 4,527 | ||
| Diagoras Rodos | 3,700 | ||
| Doxa Drama | Doxa Drama Stadium | 9,000 | |
| 26,240 | |||
| Petros Vouzounerakis Stadium | 3,000 | ||
| Ionikos | 6,000 | ||
| Karaiskakis | Municipal Agioi Anargiroi Stadium | 1,900 | |
| Levadiakos | 5,915 | ||
| Panachaiki | 11,321 | ||
| Trikala | 15,000 | ||
| Xanthi | 7,244 | ||
| Team | Manager | Captain | Kit manufacturer | Sponsor |
|---|---|---|---|---|
| Apollon Larissa | Kostas Frantzeskos | Konstantinos Chatzis | Nike | Psaragores Thalassa |
| Chania | Nikos Papadopoulos | Paschalis Kassos | Saller | Mare Magnum |
| Diagoras Rodos | Sakis Theodosiadis | Fotis Georgiou | Nike | Bread Factory |
| Doxa Drama | Kostas Vasilakakis | Alexandros Kontos | Macron | N/A |
| Ergotelis | Giannis Taousianis | Christos Batzios | Capelli | N/A |
| O.F. Ierapetra | Timos Kavakas | Christos Chrysofakis | Macron | N/A |
| Ionikos | Dimitrios Spanos | Giannis Gotsoulias | Nike | Car.gr |
| Karaiskakis | Giannis Mangos | Nikos Papanikou | Macron | Agrotikos Ptinotrofikos Syneterismos "Arta" |
| Levadiakos | Sokratis Ofrydopoulos | Zisis Karachalios | Kappa | Kompotis |
| Panachaiki | Christos Karapitsos | Nikos Kouskounas | Kappa | N/A |
| Trikala | Soulis Papadopoulos | Christos Niaros | Givova | Autodeal |
| Xanthi | Babis Tennes | Giannis Stathis | Joma | N/A |
The top six teams from Regular season will meet once (5 matches per team) for places in 2021–22 Super League Greece as well as deciding the league champion.
| Rank | Player | Club | Goals[4] |
|---|---|---|---|
| 1 |  Matías Castro | Ionikos | 15 |
| 2 | Georgios Manousakis | Ergotelis | 10 |
| 3 |  Veljko Batrović | Panachaiki | 8 |
| 4 | Tyrone Conraad | Ergotelis | 7 |
| Dimitrios Mavrias | Doxa Drama | 7 | |
| 6 |  Miguel Bianconi | Levadiakos | 6 |
| Christos Aravidis | Panachaiki | 6 | |
| Nikos Kouskounas | Panachaiki | 6 | |
| Antonis Kapnidis | Xanthi | 6 | |