| Club: | U.N.A.M. |
| Season: | 2020–21 |
| Manager: | Andrés Lillini[1] |
| Chrtitle: | President |
| Chairman: | Leopoldo Silva Gutiérrez [2] [3] |
| Stadium: | Olímpico Universitario |
| League: | Guardianes 2020 |
| League Result: | 2nd |
| League2: | Clausura 2021 |
| League Topscorer: | Guardianes 2020: Juan Ignacio Dinenno (4) |
| Season Topscorer: | Juan Ignacio Dinenno (4) |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
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The 2020–21 Universidad Nacional season is the 66th season in the football club's history and the 59th consecutive season in the top flight of Mexican football.
| Position [4] | Name |
|---|---|
| Head coach |  Andrés Lillini |
| Technical Assistant |  Israel López |
| Physical trainer | Milton Mora |
| Kinesiologist | Miguel Márquez |
| Doctor | Antonio Acevedo |
| Doctor | Joaquín Ledesma |
Universidad Nacional started their 2020–21 campaign by taking part in the Copa por México, being placed in Group A alongside América, Cruz Azul, and Toluca. The matches were announced in June 2020.[5] UNAM will also play a friendly Clásico Capitalino rivalry match with Club América in Carson, California.[6]
See main article: 2020–21 Liga MX season.
See main article: Guardianes 2020 Liga MX playoffs.