| Champ: |  Madison Keys |
| Runner: | Caroline Wozniacki |
| Score: | 7–6(7–5), 6–3 |
| Draw: | 56 |
| Seeds: | 16 |
| Type: | singles doubles |
| Before Name: | Volvo Car Open – Singles |
| After Name: | Volvo Car Open – Singles |
| After Year: | 2021 |
| Main Name: | Charleston Open |
See main article: 2019 Volvo Car Open. Kiki Bertens was the defending champion,[1] but lost in the third round to Maria Sakkari.
Madison Keys won the title, defeating Caroline Wozniacki in the final, 7–6(7–5), 6–3. This was the final WTA tour singles final Wozniacki participated in before her first retirement in January 2020.
The top eight seeds received a bye into the second round.