| Champ: |  Camila Osorio |
| Runner: |  Alexandra Yepifanova |
| Score: | 6–1, 6–0 |
| After Year: | 2021 |
See main article: 2019 US Open (tennis).
Camila Osorio won the girls' singles tennis title at the 2019 US Open, defeating Alexandra Yepifanova 6−1, 6−0 in the final.
Wang Xiyu was the defending champion, but she competed in the women's singles as a lucky loser losing to Kirsten Flipkens in the first round.
Romana Čisovská