| Date: | 29 July – 4 August |
| Edition: | 1st |
| Draw: | 32S / 8D |
| Category: | WTA 125K series |
| Location: | Karlsruhe, Germany |
| Venue: | TC Rüppurr |
| Surface: | Clay |
| Prize Money: | $125,000 |
| Champs: |  Patricia Maria Țig |
| Champd: |  Lara Arruabarrena /  Renata Voráčová |
| After Year: | 2021 |
The 2019 Karlsruhe Open (also known as the Liqui Moly Open Karlsruhe for sponsorship reasons) was a professional tennis tournament played on outdoor clay courts. It was the 1st edition of the tournament and part of the 2019 WTA 125K series, offering a total of $125,000 in prize money. It took place in Karlsruhe, Germany between 29 July and 4 August 2019.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Tamara Zidanšek | 55 | 1 | ||
 Belgium | Alison Van Uytvanck | 65 | 2 | |
| Tatjana Maria | 70 | 3 | ||
| Laura Siegemund | 71 | 4 | ||
 Australia | Daria Gavrilova | 85 | 5 | |
| Romania | Sorana Cîrstea | 94 | 6 | |
| Romania | Irina-Camelia Begu | 98 | 7 | |
| Stefanie Vögele | 112 | 8 |
The following players received a wildcard into the singles main draw:
The following players qualified into the singles main draw:
The following player received entry into the main draw as a lucky loser:
Ana Bogdan → replaced by Elena-Gabriela Ruse
Ekaterine Gorgodze
Kristína Kučová → replaced by Patricia Maria Țig
Mandy Minella → replaced by Bibiane Schoofs
Natalia Vikhlyantseva → replaced by 
Han Xinyun Irina-Camelia Begu (left thigh injury) Tereza Martincová (right thigh injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Spain | Lara Arruabarrena | Czech Republic | Renata Voráčová | 149 | 1 | |
| Russian Federation | Natela Dzalamidze | Russian Federation | Yana Sizikova | 188 | 2 | |
| Belgium | Greet Minnen | Belgium | Alison Van Uytvanck | 254 | 3 | |
| Romania | Jaqueline Cristian | Romania | Elena-Gabriela Ruse | 318 | 4 |
The following pair received a wildcard into the doubles main draw:
See main article: 2019 Karlsruhe Open – Singles.
Patricia Maria Țig def. Alison Van Uytvanck 3–6, 6–1, 6–2See main article: 2019 Karlsruhe Open – Doubles.
Lara Arruabarrena / Renata Voráčová def. Han Xinyun / Yuan Yue 6–7(2–7), 6–4, [10–4]