| Date: | 26 August – 1 September |
| Edition: | 14th |
| Surface: | Clay |
| Location: | Como, Italy |
| Champs: |  Facundo Mena |
| Champd: | Andre Begemann /  Florin Mergea |
| After Year: | 2021 |
The 2019 Città di Como Challenger was a professional tennis tournament played on clay courts. It was the fourteenth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Como, Italy between 26 August and 1 September 2019.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Stefano Travaglia | 81 | 1 | |
| Italy | Salvatore Caruso | 102 | 2 | |
| Pedro Sousa | 125 | 3 | ||
| Blaž Rola | 127 | 4 | ||
| Italy | Lorenzo Giustino | 128 | 5 | |
 Slovakia | Andrej Martin | 137 | 6 | |
| Italy | Filippo Baldi | 145 | 7 | |
| Italy | Alessandro Giannessi | 149 | 8 | |
| Argentina | Facundo Bagnis | 165 | 9 | |
 Austria | Sebastian Ofner | 168 | 10 | |
 Spain | Tommy Robredo | 184 | 11 | |
 Australia | Christopher O'Connell | 220 | 12 | |
| Viktor Galović | 223 | 13 | ||
| Alejandro Tabilo | 236 | 14 | ||
 Brazil | Thomaz Bellucci | 254 | 15 | |
 Russian Federation | Aslan Karatsev | 260 | 16 |
The following players received wildcards into the singles main draw:
Francesco Forti Federico Iannaccone Lorenzo Musetti Julian Ocleppo Giulio ZeppieriThe following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2019 Città di Como Challenger – Singles.
Facundo Mena def. Andrej Martin 2–6, 6–4, 6–1.See main article: 2019 Città di Como Challenger – Doubles.
Florin Mergea def. Fabrício Neis / Pedro Sousa 5–7, 7–5, [14–12].
