| Champ: |  Gustavo Fernández |
| Runner: |  Stefan Olsson |
| Score: | 7–5, 6–3 |
| Before Name: | Australian Open – Wheelchair men's singles |
| After Name: | Australian Open – Wheelchair men's singles |
See main article: 2019 Australian Open.
Gustavo Fernández defeated Stefan Olsson in the final, 7–5, 6–3 to win the men's singles wheelchair tennis title at the 2019 Australian Open. It was his second Australian Open singles title and third major singles title overall.
Shingo Kunieda was the defending champion, but was defeated by Olsson in the semifinals.