The 2018 Open Sopra Steria de Lyon was a professional tennis tournament played on clay courts. It was the 3rd edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Lyon, France, between 11 and 17 June 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Roberto Carballés Baena | 76 | 1 | |
 Austria | Gerald Melzer | 111 | 2 | |
| Pedro Sousa | 120 | 3 | ||
| Spain | Pablo Andújar | 128 | 4 | |
 France | Quentin Halys | 135 | 5 | |
| Henri Laaksonen | 137 | 6 | ||
 Russian Federation | Alexey Vatutin | 140 | 7 | |
| France | Corentin Moutet | 141 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2018 Open Sopra Steria de Lyon – Singles.
Félix Auger-Aliassime def. Johan Tatlot 6–7(3–7), 7–5, 6–2.See main article: 2018 Open Sopra Steria de Lyon – Doubles.
Elliot Benchetrit / Geoffrey Blancaneaux def. Hsieh Cheng-peng / Luca Margaroli 6–3, 4–6, [10–7].
