| Date: | 19–24 February |
| Edition: | 5th |
| Draw: | 32S / 32Q / 16D |
| Surface: | Hard |
| Location: | Cuernavaca, Mexico |
| Champs: |  Dennis Novikov |
| Champd: |  Roberto Maytín /  Fernando Romboli |
The 2018 Morelos Open was a professional tennis tournament played on outdoor hard courts. It was the fifth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Cuernavaca, Mexico between 19–24 February 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Slovakia | Andrej Martin | 130 | 1 | |
| United States | Kevin King | 183 | 2 | |
| United States | Dennis Novikov | 193 | 3 | |
| United States | Evan King | 196 | 4 | |
| Marcelo Arévalo | 209 | 5 | ||
 Australia | Thanasi Kokkinakis | 216 | 6 | |
 Serbia | Peđa Krstin | 230 | 7 | |
 Kazakhstan | Dmitry Popko | 254 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2018 Morelos Open – Singles.
Dennis Novikov def. Christian Garín 6–4, 6–3.See main article: 2018 Morelos Open – Doubles.
Roberto Maytín / Fernando Romboli def. Evan King / Nathan Pasha 7–5, 6–3.
