| Champ: |  Egor Gerasimov |
| Runner: | Sergey Betov |
| Score: | 7–6(7–3), 2–0 ret. |
| Type: | singles doubles |
| After Year: | no |
See main article: article and 2018 Karshi Challenger.
Egor Gerasimov was the defending champion and successfully defended his title.
Gerasimov won the title after Sergey Betov retired trailing 6–7(3–7), 0–2 in the final.