The 2018 Internationaux de Tennis de Blois was a professional tennis tournament played on clay courts. It was the sixth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Blois, France between 18 and 24 June 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Pedro Sousa | 127 | 1 | ||
 France | ||||
| Henri Laaksonen | 138 | 3 | ||
 Argentina | Juan Ignacio Londero | 163 | 4 | |
 Canada | Félix Auger-Aliassime | 170 | 5 | |
| Argentina | Carlos Berlocq | 171 | 6 | |
| France | Stéphane Robert | 174 | 7 | |
| Christian Garín | 179 | 8 |
The following players received wildcards into the singles main draw:
Jaimee Floyd Angele Calvin Hemery Alexandre Müller Stéphane RobertThe following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
Tristan Lamasine Jules Okala
Mikael YmerThe following player received entry as a lucky loser:
See main article: 2018 Internationaux de Tennis de Blois – Singles.
Félix Auger-Aliassime 6–4, 6–4.See main article: 2018 Internationaux de Tennis de Blois – Doubles.
Fabrício Neis / 
David Vega Hernández def. Hsieh Cheng-peng / 
Rameez Junaid 7–6(7–4), 6–1.
