The 2018 Delray Beach Open was a professional tennis tournament played on hard courts. It was the 26th edition of the tournament, and part of the World Tour 250 category of the 2018 ATP World Tour. It took place in Delray Beach, United States between February 19 and February 25, 2018. Unseeded Frances Tiafoe, who entered the draw on a wildcard, won the singles title.
| width=70 | Country | width=175 | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| Jack Sock | 8 | 1 | |||
 Argentina | Juan Martín del Potro | 9 | 2 | ||
| Sam Querrey | 12 | 4 | |||
 Australia | |||||
| John Isner | 18 | 6 | |||
 France | |||||
 Korea, Republic of | Chung Hyeon | 30 | 8 | ||
 Canada | Milos Raonic | 31 | 9 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Nick Kyrgios → replaced by 
Cameron Norrie Adrian Mannarino → replaced by Peter Polansky| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Bob Bryan | Mike Bryan | 30 | 1 | |||
 Belarus | Max Mirnyi |  Austria | Philipp Oswald | 92 | 2 | |
 Japan | Ben McLachlan | France | Hugo Nys | 96 | 3 | |
| Nicholas Monroe | Australia | John-Patrick Smith | 100 | 4 |
The following pairs received wildcards into the main draw:
The following pair received entry as alternates:
See main article: article and 2018 Delray Beach Open – Singles.
Frances Tiafoe defeated Peter Gojowczyk, 6–1, 6–4See main article: article and 2018 Delray Beach Open – Doubles.
Jack Sock / Jackson Withrow defeated Nicholas Monroe / John-Patrick Smith, 4–6, 6–4, [10–8]
