The 2016 Savannah Challenger was a professional tennis tournament played on clay courts. It was the seventh edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Savannah, Georgia, United States between April 18 and April 24, 2016.
| Country | Player | Rank | Seed | |
|---|---|---|---|---|
| 59 | 1 | |||
| Donald Young | 83 | 2 | ||
| Tim Smyczek | 117 | 3 | ||
 Austria | 122 | 4 | ||
 Georgia | Nikoloz Basilashvili | 126 | 5 | |
| 128 | 6 | |||
 Argentina | Facundo Argüello | 143 | 7 | |
| Jared Donaldson | 144 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players entered as a lucky loser:
Robin StaněkSee main article: 2016 Savannah Challenger – Singles.
Bjorn Fratangelo def. Jared Donaldson, 6–1, 6–3See main article: 2016 Savannah Challenger – Doubles.
Brian Baker / Ryan Harrison def. 
Purav Raja / Divij Sharan, 5–7, 7–6(7–4), [10–8]
