| Year: | 2016 |
| Team: | Mississippi Valley State Delta Devils |
| Sport: | football |
| Conference: | Southwestern Athletic Conference |
| Division: | East Division |
| Short Conf: | SWAC |
| Record: | 1–10 |
| Conf Record: | 1–8 |
| Head Coach: | Rick Comegy |
| Hc Year: | 3rd |
| Off Coach: | Ray Caldwell |
| Oc Year: | 1st |
| Def Coach: | Vincent Dancy |
| Dc Year: | 2nd |
| Stadium: | Rice–Totten Stadium |
The 2016 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2016 NCAA Division I FCS football season. Led by third-year head coach Rick Comegy, the Delta Devils compiled an overall record of 1–10 and a mark of 1–8 in conference play, placing last out of five teams in the SWAC's East Division. Mississippi Valley State played home games at Rice–Totten Stadium in Itta Bena, Mississippi.