| Year: | 2016 |
| Team: | McNeese State Cowboys |
| Sport: | football |
| Conference: | Southland Conference |
| Short Conf: | Southland |
| Record: | 6–5 |
| Conf Record: | 5–4 |
| Head Coach: | Lance Guidry |
| Hc Year: | 1st |
| Off Coach: | Landon Hoefer |
| Oc Year: | 1st |
| Def Coach: | Tony Restivo |
| Dc Year: | 1st |
| Stadium: | Cowboy Stadium |
The 2016 McNeese State Cowboys football team represented McNeese State University as a member of the Southland Conference during the 2016 NCAA Division I FCS football season. Led by first-year head coach Lance Guidry, the Cowboys compiled an overall record of 6–5 with a mark of 5–4 in conference play, tying for fourth place in the Southland. McNeese State played home games at Cowboy Stadium in Lake Charles, Louisiana.
See also: Tarleton State Texans. Sources:
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----See also: Incarnate Word Cardinals football and 2016 Incarnate Word Cardinals football team. Sources: Box Score
----See also: Nicholls State Colonels football and 2016 Nicholls State Colonels football team. Sources:
----See also: Southeastern Louisiana Lions football and 2016 Southeastern Louisiana Lions football team. Sources:
----See also: Central Arkansas Bears football, 2016 Central Arkansas Bears football team and Red Beans and Rice Bowl. Sources:
----See also: Northwestern State Demons football, 2016 Northwestern State Demons football team and McNeese State–Northwestern State football rivalry. Sources:
----See also: Abilene Christian Wildcats football and 2016 Abilene Christian Wildcats football team. Sources:
----See also: Sam Houston State Bearkats football and 2016 Sam Houston State Bearkats football team. Sources:
----See also: Lamar Cardinals football, 2016 Lamar Cardinals football team and Battle of the Border (Lamar–McNeese State). Sources:
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