| Champ: |  Diego Schwartzman |
| Runner: | Grigor Dimitrov |
| Score: | 6–7(5–7), 7–6(7–4), 6–0 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: 2016 Istanbul Open.
Roger Federer was the defending champion, but chose not to participate this year.
Diego Schwartzman won the title, defeating Grigor Dimitrov in the final, 6–7(5–7), 7–6(7–4), 6–0.
The top four seeds receive a bye into the second round.