| Champ: | Pablo Cuevas |
| Runner: |  Pablo Carreño Busta |
| Score: | 7–6(7–4), 6–3 |
| Type: | singles doubles |
See main article: 2016 Brasil Open. Pablo Cuevas was the defending champion and successfully defended his title, defeating Pablo Carreño Busta in the final, 7–6(7–4), 6–3.
The top four seeds receive a bye into the second round.