The 2016 BRD Năstase Țiriac Trophy was a tennis tournament played on outdoor clay courts and held at Arenele BNR in Bucharest, Romania, from 18 to 25 April 2016. It was the 24th edition of the BRD Năstase Țiriac Trophy tournament, and part of the ATP World Tour 250 series of the 2016 ATP World Tour.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Australia | Bernard Tomic | 21 | 1 | |
| Ivo Karlović | 30 | 2 | ||
 Argentina | Federico Delbonis | 36 | 3 | |
 Spain | Guillermo García-López | 38 | 4 | |
 Cyprus | Marcos Baghdatis | 40 | 5 | |
| Argentina | Guido Pella | 47 | 6 | |
 Italy | Paolo Lorenzi | 53 | 7 | |
 France | Paul-Henri Mathieu | 58 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Nicolas Mahut →replaced by Marco Cecchinato| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Romania | Florin Mergea | Romania | Horia Tecău | 17 | 1 | |
 United States | Eric Butorac | United States | Scott Lipsky | 91 | 2 | |
| Argentina | Guillermo Durán | Argentina | Máximo González | 103 | 3 | |
 Israel | Jonathan Erlich |  United Kingdom | Colin Fleming | 110 | 4 |
The following pairs received wildcards into the doubles main draw:
Federico Delbonis (lower back injury) Fernando Verdasco defeated Lucas Pouille, 6–3, 6–2 Florin Mergea / Horia Tecău defeated Chris Guccione / 
André Sá, 7–5, 6–4
