The 2016 Mexican Open was a professional tennis tournament played on outdoor hard courts. It was the 23nd edition of the men's tournament (16th for the women), and part of the 2016 ATP World Tour and the 2016 WTA Tour. It took place in Acapulco, Mexico between 22 and 27 February 2016, at the Princess Mundo Imperial.
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q3 | width=85 | Q2 | width=85 | Q1 |
| Men's singles | 500 | 300 | 180 | 90 | 45 | 0 | 20 | 10 | 0 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Men's doubles | 0 | 45 | 25 | |||||||||||
| Women's singles | 280 | 180 | 110 | 60 | 30 | 1 | 18 | 14 | 10 | 1 | ||||
| Women's doubles | 1 |
| Event | W | F | SF | QF | Round of 16 | Round of 321 | width=85 | Q3 | width=85 | Q2 | width=85 | Q1 |
| Men's singles | $343,000 | $154,620 | $73,240 | $35,340 | $18,020 | $9,910 | $1,115 | $615 | ||||
| Men's doubles | $101,310 | $45,710 | $21,550 | $10,420 | $5,350 | |||||||
| Women's singles | $43,000 | $21,400 | $11,300 | $5,900 | $3,310 | $1,925 | $1,005 | $730 | $530 | |||
| Women's doubles | $12,300 | $6,400 | $3,435 | $1,820 | $960 | |||||||
| Doubles prize money per team | ||||||||||||
| Country | Player | Ranking1 | Seed | |
|---|---|---|---|---|
 Spain | David Ferrer | 6 | 1 | |
 Japan | Kei Nishikori | 7 | 2 | |
| Marin Čilić | 12 | 3 | ||
 Austria | Dominic Thiem | 19 | 4 | |
 Australia | Bernard Tomic | 20 | 5 | |
| Ivo Karlović | 26 | 6 | ||
| Grigor Dimitrov | 28 | 7 | ||
 France | Jérémy Chardy | 30 | 8 |
The following players received wildcards into the main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Dudi Sela
Milos Raonic → replaced by 
Dmitry Tursunov| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Colombia | Juan Sebastián Cabal | Colombia | Robert Farah | 50 | 1 | |
| Raven Klaasen | Rajeev Ram | 54 | 2 | |||
| Austria | Alexander Peya | Philipp Petzschner | 63 | 3 | ||
| Treat Huey |  Belarus | Max Mirnyi | 65 | 4 |
The following pairs received wildcards into the main draw:
The following pair received entry from the qualifying draw:
| Country | Player | Ranking1 | Seed | |
|---|---|---|---|---|
| Belarus | Victoria Azarenka | 15 | 1 | |
| Sloane Stephens | 24 | 2 | ||
| Russian Federation | Anastasia Pavlyuchenkova | 25 | 3 | |
 United Kingdom | Johanna Konta | 27 | 4 | |
 Belgium | Alison Van Uytvanck | 42 | 5 | |
 Sweden | Johanna Larsson | 48 | 6 | |
 Montenegro | Danka Kovinić | 50 | 7 | |
| Belgium | Yanina Wickmayer | 53 | 8 |
The following players received wildcards into the main draw:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Alexandra Dulgheru → replaced by Lourdes Domínguez Lino
Madison Keys → replaced by 
Anett Kontaveit
Karin Knapp → replaced by Lara Arruabarrena
Magdaléna Rybáriková → replaced by Monica Puig Victoria Azarenka (left wrist injury)
Urszula Radwańska (left ankle injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Spain | Anabel Medina Garrigues | Spain | Arantxa Parra Santonja | 69 | 1 | |
| Kiki Bertens | Sweden | Johanna Larsson | 103 | 2 | ||
| Spain | Lara Arruabarrena |  Brazil | Paula Cristina Gonçalves | 132 | 3 | |
| United Kingdom | Jocelyn Rae | United Kingdom | Anna Smith | 136 | 4 |
The following pairs received wildcards into the main draw:
The following pair received entry as alternates:
María-Teresa Torró-Flor (right rib injury)See main article: 2016 Abierto Mexicano Telcel – Men's singles.
Dominic Thiem defeated Bernard Tomic, 7–6(8–6), 4–6, 6–3See main article: 2016 Abierto Mexicano Telcel – Women's singles.
Sloane Stephens defeated Dominika Cibulková, 6–4, 4–6, 7–6(7–5)See main article: 2016 Abierto Mexicano Telcel – Men's doubles.
Max Mirnyi defeated Philipp Petzschner / Alexander Peya, 7–6(7–5), 6–3See main article: 2016 Abierto Mexicano Telcel – Women's doubles.
Anabel Medina Garrigues / Arantxa Parra Santonja defeated Kiki Bertens / Johanna Larsson, 6–0, 6–4