| Champ: | Roger Federer |
| Runner: |  Milos Raonic |
| Score: | 6–4, 6–7(2–7), 6–4 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| After Name: | Brisbane International – Men's singles |
| Before Name: | Brisbane International – Men's singles |
See main article: 2015 Brisbane International.
Lleyton Hewitt was the defending champion, but lost to compatriot Sam Groth in the first round.
Roger Federer won the title, defeating Milos Raonic in the final, 6–4, 6–7(2–7), 6–4, and in the process recorded his 1,000th match victory on the professional tour.
The top four seeds receive a bye into the second round.
See also: 1. Roger Federer (champion)
See also: 2. 
Kei Nishikori (semifinals)
See also: 3. Milos Raonic (final)
See also: 4. Grigor Dimitrov (semifinals)
See also: 5. Kevin Anderson (first round)
See also: 6. 
Gilles Simon (first round)
See also: 7. 
Alexandr Dolgopolov (second round)
See also: 8. Julien Benneteau (first round)
See also: 1 and 1. Tobias Kamke (second round)
See also: 2 and 2. 
Viktor Troicki (qualifying competition)
See also: 3 and 3. 
Marsel İlhan (qualifying competition)
See also: 4 and 4. Pierre-Hugues Herbert (second round)
See also: 5 and 3. 
Tim Smyczek (second round)
See also: 6 and 2. Denis Kudla (qualified)
See also: 7 and 4. 
Norbert Gombos (second round)
See also: 8 and 1. Lucas Pouille (first round)