See main article: 2013 Bank of the West Classic.
Serena Williams was the two-time defending champion, but she decided not to participate this year.
Dominika Cibulková won the title, defeating Agnieszka Radwańska in the final, 3–6, 6–4, 6–4.
The top four seeds received a bye into the second round.
The top six seeds received a bye into the second round.