| Champ: |  Petra Kvitová |
| Runner: |  Maria Kirilenko |
| Score: | 7–6(11–9), 7–5 |
| Draw: | 30 |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: 2012 New Haven Open at Yale.
Caroline Wozniacki was the four-time defending champion. She retired in the semifinals against Maria Kirilenko.
Petra Kvitová defeated Kirilenko 7–6(11–9), 7–5 in the final.
The top two seeds receive a bye into the second round.
