See main article: 2012 Internazionali Femminili di Palermo.
Anabel Medina Garrigues was the defending champion, but lost to Maria Elena Camerin in the first round.
Top seed Sara Errani won the title by beating Barbora Záhlavová-Strýcová 6–1, 6–3 in the final. She did not drop a set the entire tournament.
