The 2012 Internazionali Femminili di Palermo was a professional women's tennis tournament played on outdoor clay courts. It was the 25th edition of the tournament which was part of the 2012 WTA Tour. It took place in Palermo, Italy between 9 July and 15 July 2012. First-seeded Sara Errani won the singles title.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Sara Errani[1] | 10 | 1 | |
| Italy | Roberta Vinci[2] | 23 | 2 | |
| Julia Görges | 24 | 3 | ||
 Spain | Anabel Medina Garrigues | 28 | 4 | |
| Spain | Carla Suárez Navarro | 40 | 5 | |
| Polona Hercog | 46 | 6 | ||
 France | Alizé Cornet | 60 | 7 | |
 Czech Republic | Barbora Záhlavová-Strýcová | 62 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky loser:
Kaia Kanepi (heels)
Alexandra Panova
Shahar Peer
Agnieszka Radwańska (upper respiratory illness) Francesca Schiavone (bronchitis)
Galina Voskoboeva Klára Zakopalová| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Czech Republic | Renata Voráčová | Czech Republic | Barbora Záhlavová-Strýcová | 106 | 1 | |
| Darija Jurak | Katalin Marosi | 163 | 2 | |||
| Russian Federation | Vera Dushevina | Edina Gallovits-Hall | 171 | 3 | ||
| Russian Federation | Elena Bovina | Alizé Cornet | 191 | 4 |
The following pairs received wildcards into the doubles main draw:
Anna Tatishvili (right thigh strain)See main article: 2012 Internazionali Femminili di Palermo – Singles.
Sara Errani defeated Barbora Záhlavová-Strýcová, 6–1, 6–3See main article: 2012 Internazionali Femminili di Palermo – Doubles.
Renata Voráčová / Barbora Záhlavová-Strýcová defeated Darija Jurak / 
Katalin Marosi, 7–6(7–5), 6–4
