The 2012 Barcelona Ladies Open was a women's tennis tournament played on outdoor clay courts. It was the 6th edition of the Barcelona Ladies Open, and an International-level tournament on the 2012 WTA Tour. It took place at the Centre Municipal Tennis Vall d'Hebron in Barcelona, Catalonia, Spain between April 9 and 15, 2012. Sara Errani won the singles title.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Francesca Schiavone | 12 | 1 | |
| Julia Görges | 15 | 2 | ||
 Slovakia | Dominika Cibulková | 18 | 3 | |
| Italy | Roberta Vinci | 19 | 4 | |
| Italy | Flavia Pennetta | 24 | 5 | |
 Czech Republic | Petra Cetkovská | 28 | 6 | |
| Italy | Sara Errani | 31 | 7 | |
| Polona Hercog | 37 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Elena Baltacha (right foot injury)
María José Martínez Sánchez (right thigh injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Italy | Sara Errani | Italy | Roberta Vinci | 25 | 1 | |
| Nuria Llagostera Vives | Arantxa Parra Santonja | 41 | 2 | |||
 Belarus | Olga Govortsova | Vladimíra Uhlířová | 82 | 3 | ||
 Russian Federation | Nina Bratchikova | Darija Jurak | 137 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2012 Barcelona Ladies Open – Singles.
Sara Errani defeated Dominika Cibulková 6–2, 6–2See main article: 2012 Barcelona Ladies Open – Doubles.
Sara Errani / Roberta Vinci defeated Flavia Pennetta / Francesca Schiavone, 6–0, 6–2
