| Competition: | Liga Panameña de Fútbol |
| Season: | 2012–13 |
| Winners: | Apertura: Árabe Unido Clausura: Sporting San Miguelito |
| Relegated: | Atlético Chiriquí |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Árabe Unido Sporting San Miguelito |
| Prevseason: | 2011–12 |
| Nextseason: | 2013–14 |
The 2012–13 Liga Panameña de Fútbol season is the 25th season of top-flight football in Panama. The season began on 20 July 2012 and is scheduled to end in May 2013. Ten teams will complete throughout the entire season.
Colón C-3 finished in 10th place in the overall table last season and were relegated to the Liga Nacional de Ascenso. Taking their place for this season are the overall champions of last season's Liga Nacional de Ascenso, Río Abajo F.C.
The 2012 Apertura is the first tournament of the season. It began on 20 July 2012 and ended on 2 December 2012.
----
Arabe Unido won 5-1 on aggregate.----Chepo FC won 3-1 on aggregate.
| No. | Player | Team | Goals | |
|---|---|---|---|---|
| 1 |  Jorman Aguilar | Río Abajo | 10 | |
| 2 | Edwin Aguilar | Tauro | 10 | |
| 3 | Anthony Basile | Río Abajo | 8 | |
| 4 | Bernando Palma | Chepo | 6 | |
| 5 | Cesar Medina | Alianza | 5 | |
| 6 | Armando Polo | San Francisco | 4 | |
| 7 | Renán Yoriel Addles | Chorillo | 4 | |
| 8 | Rene Campbell | Alianza | 4 | |
| 9 |  Julio Castillo | Chepo FC | 4 | |
| 10 | Angel Lombardo | Deportivo Plaza Amador | 4 |
----
San Francisco won 2-1 on aggregate.----Sporting San Miguelito won 3-2 on aggregate.
| No. | Player | Team | Goals | |
|---|---|---|---|---|
| 1 | Johnny Ruiz | Chorillo | 9 | |
| 2 | Luis Gabriel Rentería | Tauro | 8 | |
| 3 | Ricardo Clarke | Sporting San Miguelito | 7 | |
| 4 | Angel Lombardo | Plaza Amador | 7 | |
| 5 | José Luis Garcés | San Francisco | 6 | |
| 6 | René Víctor Mendieta Jr | Chepo | 6 | |
| 7 | Anthony Basile | Río Abajo | 5 | |
| 8 |  Juan Osorio | Alianza | 5 | |
| 9 | Armando Polo | Río Abajo | 5 | |
| 10 | Edwin Aguilar | Tauro | 4 |