| Event: | Women's 78 kg |
| Championship: | 2010 World Judo Championships |
| Location: | Tokyo, Japan |
| Gold: | Kayla Harrison |
| Gold Value: | 1 |
| Goldnoc: | USA |
| Silver: | Mayra Aguiar |
| Silvernoc: | BRA |
| Bronze: | Akari Ogata |
| Bronzenoc: | JPN |
| Bronze2: | Yang Xiuli |
| Bronzenoc2: | CHN |
The Women's 78 kg competition at the 2010 World Judo Championships was held at 9 September at the Yoyogi National Gymnasium in Tokyo, Japan. Thirty-two competitors contested for the medals, being split in four pools where the winner advanced to the medal round.