| Champ: | Caroline Wozniacki |
| Runner: |  Elena Dementieva |
| Score: | 1–6, 6–2, 6–3 |
| Type: | singles doubles |
| Draw: | 56 (8 / 3) |
| Seeds: | 16 |
| Before Name: | Toray Pan Pacific Open – Singles |
| After Name: | Toray Pan Pacific Open – Singles |
| Main Name: | Pan Pacific Open |
See main article: 2010 Toray Pan Pacific Open.
Caroline Wozniacki defeated Elena Dementieva in the final, 1–6, 6–2, 6–3 to win the singles tennis title at the 2010 Pan Pacific Open. It was Dementieva's last WTA Tour singles final before her retirement from the sport later that year.
Maria Sharapova was the defending champion, but lost in the first round to Kimiko Date-Krumm.
The top eight seeds receive a bye into the second round.