See main article: 2010 Shanghai Rolex Masters.
Andy Murray defeated Roger Federer in the final, 6–3, 6–2 to win the singles tennis title at the 2010 Shanghai Masters.
Nikolay Davydenko was the defending champion, but lost in the second round to Mischa Zverev.
Rafael Nadal's loss in the third round ended his record streak of 21 consecutive Masters 1000 quarterfinals.
The top eight seeds receive a bye into the second round.