See main article: 2010 Monte-Carlo Rolex Masters.
Five-time defending champion Rafael Nadal defeated Fernando Verdasco in the final, 6–0, 6–1 to win the singles tennis title at the 2010 Monte-Carlo Masters. It was his first title in 11 months, and he lost only 14 games and no sets en route to the title.
The top eight seeds receive a bye into the second round.